Which class of cell adhesion molecules (CAMs) is known for mediating cell-cell adhesion through cadherins?

The correct answer is cadherins, which are a specific class of cell adhesion molecules (CAMs) that play a critical role in mediating cell-cell adhesion. Cadherins are a type of transmembrane protein that facilitate the binding between adjacent cells by adhering to one another through their extracellular domains. This interaction is calcium-dependent, meaning that calcium ions are required for cadherins to maintain their adhesive properties.

Cadherins are integral for maintaining tissue structure and integrity by forming adherens junctions, which are essential not only for cell adhesion but also for transmitting signals required for various cellular processes, such as differentiation and proliferation. They are particularly important in embryonic development and in maintaining the architecture of tissues in mature organisms.

Other classes of CAMs have different functions. For instance, Ig CAMs (Immunoglobulin-like CAMs) are involved in immune responses and leukocyte interactions. Integrins are primarily associated with cell-matrix adhesion and play a key role in connecting the cytoskeleton to the extracellular matrix. Selectins mediate transient interactions between leukocytes and the endothelium during immune responses, particularly in the process of rolling and adhesion of white blood cells. Each of these CAMs has a unique role in cellular interactions,